There is a huge weight of expectation on the Liverpool star’s shoulders to spearhead his nation to a record-extending eighth AFCON triumph in Cameroon after his scintillating form at club level.
But Egypt face a difficult start in their quest to reclaim the title they won three times in a row between 2006-10, with three-time winners Nigeria no doubt also confident of making a deep run in the competition after a semi-final tilt three years ago.
Date, kick-off time and venue
Nigeria vs Egypt is scheduled for a 4pm GMT kick-off on Tuesday January 11, 2022.
The match will take place at the Stade Omnisport de Garoua in Garoua, northern Cameroon.
Where to watch Nigeria vs Egypt
TV channel: In the UK, Nigeria vs Egypt will be televised live on Sky Sports Premier League, Football and Main Event.
Live stream: Sky Sports subscribers will be able to watch the match online via the website or Sky Go app. Coverage is also available via the BBC website and iPlayer.
Live blog: You can follow all the action with Standard Sport’s up-to-the-minute LIVE blog.
Nigeria vs Egypt team news
Nigeria’s hopes of a fourth Africa Cup of Nations crown have been hit by the absences of key forwards Emmanuel Dennis and Victor Osimhen, who remain with Watford and Napoli respectively.
Rangers’ Leon Balogun and Omonia Nicosia’s Shehu Abdullahi also withdrew from Augustine Eguavoen’s 28-man tournament squad, with Henry Onyekuru, Tyronne Ebuehi, Peter Olayinka and West Brom’s Semi Ajayi called up instead.
Nigeria are also missing former Manchester United loanee Odion Ighalo, who was not permitted to leave Saudi Arabian club Al-Shabab as Jamilu Collins was drafted in.
As for Egypt, left-back Mohamed Hamdi has been ruled out of AFCON with a knee injury and Ibrahim Adel and goalkeeper Mohamed Abo-Gabal are among those to have tested positive for Covid-19.
Nigeria vs Egypt prediction
This is the tie of the tournament so far between two sides who will expect to figure in the latter stages.
Having Salah in their ranks is obviously an enormous boost for Egypt, but their supporting cast - not a patch on what he is used to at Liverpool - will need to step up consistently if he is to showcase his best form in Cameroon.
The absences of Dennis, Osimhen and Ighalo are big blows for Nigeria, who may well struggle for goals.
We’re plumping for Egypt to kick off their campaign with a statement victory.
Egypt 2-0 Nigeria.
Head to head (h2h) history and results
Nigeria wins: 8
Egypt wins: 5