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The Super Eagles are many people's favourites for the tournament after topping their group with three wins from three against Egypt, Sudan and Guinea-Bissau.
Tunisia, on the other hand, scraped through as one of the best third-placed teams.
After their first game against Mali finished in chaos after the referee twice signalled for full-time early, Tunisia then beat Mauritania before losing to Gambia to leave them with the daunting task of facing Nigeria.
Here’s everything you need to know about the game in Garoua.
Date, kick-off time and venue
The AFCON round of 16 clash is scheduled for a 7pm GMT kick-off time on Sunday January 23, 2022.
The Roumde Adija Stadium in Garoua will host it.
Where to watch Nigeria vs Tunisia
TV channel: The game will be broadcast on Sky Sports Mix.
Live stream: Sky Sports subscribers will be able to watch the game through the Sky Go App.
Live blog: Get minute-by-minute updates through Standard Sport’s dedicated match blog.
Nigeria vs Tunisia team news
Nigeria XI: Okoye; Aina, Troost-Ekong, Omeruo, Sanusi; Ndidi, Aribo; Chukwueze, Simon, Iheanacho; Awoniyi.
Tunisia XI: Ben Said; Haddadi, Ifa, Talbi, Drager; Laidouni, Skhiri, Ben Slimane; Msakni, Jaziri, Rafia.
Nigeria vs Tunisia prediction
Frankly, it’s too hard to look past the Super Eagles following their performances in the group stage.
Nigeria to win 2-0.
Head to head (h2h) history and results
Nigeria wins: 6
Tunisia wins: 6