The 2020 NFL season will get off and running on Thursday when the Kansas City Chiefs begin the defence of their Super Bowl title.
Kansas City will welcome the Houston Texans to Arrowhead Stadium to begin a campaign that promises to be like no other.
Just how will a season significantly impacted by the coronavirus pandemic work?
We answer all the pertinent questions around the campaign in our guide to the 2020 season.
Will there be a bubble?
While the NBA has enjoyed success with its bubble, there are no such plans in the NFL. Teams will cross the country for games as normal, though they will not be permitted to travel on the day of a game.
Players were subjected to daily testing during training camp and that will remain the case in the regular season, with the exception of gameday. The 'gameday' tests will take place the day before each contest.
Those who return positive tests and have symptoms will be required to wait for 10 days, experience 72 hours with no symptoms, test negative and then receive approval from a team doctor and league medical officials before being allowed to return.
Asymptomatic players can either wait at least five days and test negative twice before being permitted to return, or wait 10 days.
Both the home and away teams are required to stay in a hotel the night before a game, with the visiting team essentially quarantined.
Face masks are not mandatory for players standing on the sideline, except at the San Francisco 49ers' Levi's Stadium and the Buffalo Bills' home stadium in Orchard Park, because of local regulations.
The NFL worked with Oakley to develop face shields to help stop the spread of COVID-19 during games, but it is not mandatory for players to have them fitted.
Players were given the chance to opt out of the season, and plenty took that opportunity with one team hit harder than any other in the league.
Who are the opt outs?
A total of 66 players took the opportunity to opt out of the 2020 campaign, including eight members of the New England Patriots.
The Patriots defense will have a significantly different look as linebacker Dont'a Hightower and safety Patrick Chung elected to skip the season.
Hightower and Chung each played key roles in three of the Patriots' six Super Bowl titles and New England may struggle to hold on to their AFC East title without the spine of their defense.
A Patriots division rival will also be light at linebacker as a result of an opt out. C.J. Mosley of the New York Jets, a high-price free agent who played only two games last year because of a groin injury, also made the decision not to play in 2020.
Will there be fans?
In most stadiums for the meantime, the answer is an emphatic no. However, there will be spectators in attendance for the opener at Arrowhead Stadium, with the Chiefs operating at 22 per cent capacity.
The Miami Dolphins are allowing a maximum of 13,000 fans for their home opener with the Bills on September 20, while Ohio governor Mike DeWine announced the Cleveland Browns and Cincinnati Bengals will be allowed up to 6,000 attendees for their home games in September and October.
In Indianapolis, the Colts are permitting a maximum of 2,500 supporters for their first home game with the Minnesota Vikings while their AFC South rivals the Jacksonville Jaguars told season ticket holders they will seat 25 per cent of TIAA Bank Field's capacity at each 2020 home game.
The Dallas Cowboys are planning on having fans at games in 2020 but have yet to confirm the specifics of those proposals.
What were the major offseason moves?
It was a particularly wild offseason, with the headline move coming as Tom Brady sensationally left the Patriots after 20 seasons and six Super Bowl titles.
He signed with the Tampa Bay Buccaneers and was eventually joined by favourite target Rob Gronkowski, who came out of retirement and was traded from New England to Tampa.
Patriots coach Bill Belichick put his faith in Cam Newton to stay healthy and prove a worthy successor to Brady, signing the former MVP in July.
The Arizona Cardinals and Seattle Seahawks each made major moves to dethrone the San Francisco 49ers in the NFC West with trades for wide receiver DeAndre Hopkins and safety Jamal Adams respectively.
Though the most important move was made by the team that defeated the 49ers in the Super Bowl, the Chiefs locking down Patrick Mahomes for the long term with a mammoth 10-year, $503million extension, the largest contract in major North American sports history.
How will the playoffs work?
The NFL has long since operated with a 12-team postseason system, comprising of the four division winners and two wild card teams in each conference.
That format was changed this offseason as the league agreed to expand the playoffs to 14 teams.
Previously the top two seeds received a first-round bye but from 2020 onwards only the number one seed in each conference will get to rest during the Wild Card round.
Many believe the addition of two extra teams will dilute the playoff field but, with extra spots up for grabs and the increased importance of being the top seed, the final weeks of the regular season should be even more dramatic.
Any other changes?
Yes... and quite significant ones at that.
There's a new era in Washington, with a new head coach - Ron Rivera - and a new team name.
Washington ditched a nickname widely deemed as racially insensitive towards Native Americans that the franchise had used since its second year of existence in 1933 in Boston.
After bowing to pressure from the public and key sponsors, the club will spend the season known as the Washington Football Team. What direction they take with a new long-term moniker remains to be seen.
Also, remember that pass interference review system that caused so many stoppages last season and didn't really solve any problems? Yeah, that's gone.
The NFL announced back in May that it would not move forward with the pass interference review system, implemented after the Los Angeles Rams' controversial NFC Championship Game win over the New Orleans Saints in the playoffs of the 2018 season.
Given the Saints' 2019 season also ended on a pass interference non-call, it is clear the review system was not fit for purpose and did not even help the team it was meant to appease.
Who are the favourites?
Given Mahomes' comeback heroics in Super Bowl LIV and his apparent ability to overturn any deficit, it is tough to look past the Chiefs and their loaded offense.
The Baltimore Ravens and reigning MVP Lamar Jackson will be out to put last season's shock playoff exit to the Tennessee Titans behind them and prove they can stop Mahomes.
Indianapolis are viewed as prospective challengers following the acquisition of veteran quarterback Philip Rivers from the Los Angeles Chargers and All-Pro defensive tackle DeForest Buckner from the 49ers, who are the favourites to repeat as NFC champions.
Outside of those in San Francisco's NFC West division, the Saints and a Brady-led Buccaneers team that possesses ominous amounts of talents look set to provide their main challengers.