The 34-year-old played through the pain as he helped the Rams to victory at Super Bowl LVI against the Cincinnati Bengals earlier this year.
Stafford required a mid-term injection to continue and did not throw during workouts in the spring, with a specific throwing schedule during the Rams' training camp.
But he has revealed he is ready for the new campaign, and says there will be nothing to hold him back, stating: "I feel good. I'm ready to go, no limitations.
"I feel great. I'm ready to go play. [You] can always be better, can always try to feel like [you're] 21 again. But no, I feel really good. I feel like I can make every throw."
Rams coach Sean McVay echoed Stafford's comments, adding: "He's throwing the ball excellent. He feels good. Everyting that I'm seeing is reflective of everything he's saying to me."
Stafford will be looking for another strong regular season in his second year with the Rams, after throwing 41 touchdowns prior to last season's playoffs, the joint-best of his career to date (also 41 with the Detroit Lions in 2011).