Young goalkeeper Bruce Bvuma replaces the injured Itumeleng Khune in what will no doubt be a baptism of fire for him, while defender Daniel Cardoso replaces the suspended Lorenzo Gordinho.
Tsepo Masilela replaces Sibusiso Khumalo at left-back, with only Eric Mathoho and Ramahlwe Mphahlele retaining their spots from Saturday's Nedbank Cup defeat to SuperSport United.
In midfield, Zimbabwean Edmore Chirambadare returns to take the place of George Lebese and he will be assisted by Joseph Molangoane, George Maluleka and Willard Katsande.
Siphiwe Tshabalala and Bernard Parker continue to lead their attack.
City meanwhile welcomes back Mozambican defender Edmilson at left-back and at right-back Vincent Kobola also returns.
Midfield Roland Putsche is recalled in place of Thabo Nodada, so is striker Lehlohonolo Majoro returning along with winger Bhongolwethu Jayiya.
City: Walters, Kobola, Johannes, Gumede, Edmilson, Mokeke, Pustche, Manyama, Ngoma, Jayiya, Majoro
Chiefs: Bvuma, Mphahlele, Mathoho, Cardoso, Masilela, Katsande, Maluleka, Molangoane, Chirambadare, Tshabalala, Parker