Getting on base twice in three at-bats, Ohtani drove in his 89th run of the season. He also lowered his ERA to 2.43.
"I've said it before: He's the most valuable player of our game right now," interim Angels manager Phil Nevin said. "Until somebody can come in and do the things he does on both sides, I don't see it going any other way.
"I love Aaron Judge like a son, but I'll continue to say it: [Ohtani] can take over a baseball game like nobody can."
Ohtani was more modest in his own assessment however, adding: "I don't like to self-critique myself in any way. One thing I could say is, overall, balance-wise, I'm having a better season this year than I had last year."
The two-time All-Star's performance dropped the Mariners two games behind Toronto Blue Jays and a half game off the Tampa Bay Rays, leaving them five ahead of the Baltimore Orioles in the final Wild Card spot. The Angels improved to 63-82 in another disappointing year.