The Saracens playmaker has passed all his return-to-play protocols after a concussion issue just in time to start at inside centre against the Pumas.
Farrell will lead England for the first time since the 2021 autumn clash with Australia. The 31-year-old has regained the captaincy in the wake of Courtney Lawes’ absence, also due to concussion concerns.
Maro Itoje will start at blindside flanker, slotting into Lawes’ back-row enforcer role, with Northampton’s Alex Coles making his Test debut at lock.
Marcus Smith will pilot the backline from fly-half, with Manu Tuilagi stepping in at outside centre. Bristol prop Ellis Genge and Exeter wing Jack Nowell have been named as vice-captains by head coach Eddie Jones.
“It’s been a really good week of preparation and I’ve been very pleased with the squad’s attitude,” said England boss Jones. “They’ve shown real work ethic and a determination to improve and our leaders, Owen, Ellis and Jack have really lifted the team.
“We’re looking forward to a great game of rugby at a full Twickenham Stadium against a very good Argentina side. It’s been a tough time for rugby lately and we hope that these autumn games show just what a special game it is.”