According to reports, the pilot felt unwell three hours into the LATAM Airlines flight from Miami to Santiago on Monday.
The pilot, identified as 56-year-old captain Ivan Andaur by Chilean newspaper, Las Últimas Noticias, proceeded to collapse in the plane’s bathroom where he received emergency assistance from the crew.
The plane diverted to Panama City’s Tocumen International Airport.
Mr Andaur received medical assistance on arrival LATAM said, but sadly was pronounced dead a short time later.
“LATAM Airlines Group reports that flight LA505 yesterday, which was on the Miami-Santiago route, had to land at the Tocumen International Airport in Panama due to a medical emergency for one of the three members of the command crew. When the plane landed, emergency services provided life-saving help, but the pilot sadly passed away,” the airline said in a statement.
“We are deeply moved by what has happened, and we extend our sincere condolences to the family of our employee.
“We are deeply grateful for his 25-year career and his valuable contribution, which was always distinguished by his dedication, professionalism, and dedication. During the flight, all the necessary safety protocols were carried out to safeguard the life of the affected pilot.”
Following the incident, the aircraft departed Panama City on Tuesday and landed in Santiago five hours later at 11.55pm.