Antonio Conte admits squad rotation will be crucial as Tottenham prepare for the first of seven matches in the space of 20 days.
Spurs are aiming to build on their positive start to the Premier League season when they travel to Nottingham Forest on Sunday, having collected seven points from their opening three games.
Conte bolstered his squad ahead of the campaign with the likes of Ivan Perisic, Richarlison, Yves Bissouma and Djed Spence all arriving at the Tottenham Hotspur Stadium.
And the Italian knows that strength in depth will be essential for Tottenham, who also face West Ham, Fulham, Manchester City and Leicester City in the Premier League between now and September 17.
The north London side will also play the first two matches of their Champions League campaign, hosting Marseille on September 7 before heading to Portugal to face Sporting CP six days later.
"After every game, I will have to check the situation with all of the players for tiredness and injuries," Conte said.
"To tell one player that he is going to play in all seven games; it is impossible.
"I am not a magician! I cannot forecast this, but we go game by game to make the best decisions for the team and for the players.
"It is crazy to think we can put always the same players. In this transfer market, our target was to improve the squad because we know very well we have four competitions, so to have the possibility to make rotations without dropping the level is important."