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Roy Hodgson's side will most likely only need a draw against the co-hosts in Donetsk to ensure their path through to the knockout phase. Ukraine themselves need to win to maintain local interest in the tournament past the halfway stage.
Wayne Rooney returns for England following his two-match suspension, but England will be playing in front of a partisan crowd at the Donbass Arena.
Ukraine actually won the last time they faced England on their home turf - a 1-0 victory in a World Cup qualifier in 2009 - and they have legendary striker Andriy Shevchenko likely to be fit for the Group D showdown.
So, do you think England will win, lose or draw?
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On Monday, we asked you to vote on whether you thought Wayne Rooney be brought straight back into the England team against Ukraine?
The result of that poll was a win for the yes camp, though not by as much as you might expect.
Results of the poll (as of 11am on Tuesday)
Yes - 58 per cent (4,211 votes)
No - 42 per cent (2,990 votes)