Both clubs have had differing fortunes to start the season with City the only side to win all of their Premier League games as they aim to claim a fourth-straight title. United, meanwhile, have won both of their home fixtures but have been beaten in their two away games with both of those losses coming in North London to Tottenham Hotspur and Arsenal, respectively.
With four games played, data experts at Opta have simulated how the season will play out and predicted the most likely finishing position for every team. Here is where they are tipping the two Manchester clubs to finish...
Erik ten Hag will make the decision in the next day over whether to recall Jadon Sancho for the EFL Cup on Tuesday, in a significant indicator on where he stands in the Manchester United manager’s thoughts.
Harry Kane on Saturday bettered a record first set by legendary German striker Gerd Mueller when he hit a hat-trick in Bayern Munich's 7-0 rout of Bochum which took the champions back to the top of the Bundesliga.Bayern have now beaten Bochum 7-0 in three of their past five fixtures.