Chelsea continued their frustrating start to the Premier League season with a disappointing loss at Southampton – which had previously been a happy hunting ground.
The Blues took an early lead but could not hold off a Southampton comeback, leaving Thomas Tuchel's side with just two wins from their opening five league games.
Brighton and Hove Albion's unbeaten start came to an end against Fulham at Craven Cottage, Crystal Palace conceded a late equaliser against Brentford, while Leeds United and Everton shared the spoils in a fiery 1-1 draw at Elland Road.
Here, Stats Perform unpacks the pick of the data from Tuesday's fixtures in the English top flight.
Southampton 2-1 Chelsea: Sterling delivers but Saints finally sink Blues at home
Romeo Lavia and Adam Armstrong cancelled out Raheem Sterling's opener as Southampton beat Chelsea at home in the Premier League for the first time since March 2013.
Saints were winless in nine games at St Mary's against Chelsea in the competition and would have feared a familiar fate after Sterling poked home in the 23rd minute.
That marked the forward's 169th goal involvement (112 goals, 57 assists) in the top flight, a tally bettered by only Harry Kane (230) Sergio Aguero (209 and Jamie Vardy (175) since Sterling made his debut in March 2012.
But Lavia soon hit back as he became the fourth youngest Southampton player to score in the Premier League, with the recent arrival aged just 18 years and 236 days.
A smart Armstrong finish then inflicted consecutive top-flight away defeats on Chelsea for the first time under Tuchel, who may have reasons for concern after an underwhelming start to the new campaign.
Indeed, Chelsea (W2 D1 L2) have lost two or more of their first five games in a Premier League season for just the second time this century. The last time it happened, they finished 10th in 2015-16 after opening with three losses in five games.
Fulham 2-1 Brighton and Hove Albion: Mitrovic ends Seagulls' flying start
Brighton headed to Craven Cottage unbeaten in nine league games, winning six of those, but were undone by Aleksandar Mitrovic and a Lewis Dunk own goal.
Mitrovic continued his fine form in front of goal for his 48th-minute opener, scoring for a fourth time in the Premier League against the Seagulls, more than he has managed against any other side in the competition.
The Serbian's strike also marked his 100th league goal in Fulham colours before Dunk turned into his own net – his sixth Premier League own goal, more than any other player since the start of the 2016-17 season.
Richard Dunne (10), Martin Skrtel (7), Phil Jagielka (7) and Jamie Carragher (7) are the only players to find their own net more in Premier League history than Dunk, who endured a night to forget.
Alexis Mac Allister offered brief hope of sparing Dunk's blushes with a penalty, but Fulham held on to reach eight points from five games, their best start to a top-flight season since the 2012-13 term (nine points).
Crystal Palace 1-1 Brentford: Zaha-reliant Eagles suffer more London derby frustration
Wilfried Zaha continued to carry the hopes of Selhurst Park on his shoulders, but his curling effort was not enough to see Palace to a rare London derby victory.
The Ivory Coast international found the top-right corner in the 59th minute to open the scoring, his 13th goal in 20 appearances in the Premier League in 2022, as many as he managed in his previous 45 games in the competition.
Zaha has also scored six of Palace’s last seven home league goals, but the Eagles could not hold out for what would have been just a third win in their last 20 top-flight London derbies.
Yoane Wissa denied Palace in the 88th minute with a fourth league goal in his last eight games on the road.
Brentford have now avoided defeat in five of their last eight Premier League games where they conceded first (W2 D3 L3), while Palace have won just one of their last five when opening the scoring in the league.
Leeds 1-1 Everton: Lampard's men let another lead slip
Everton remain winless this season in the Premier League (D3 L2), despite taking the lead at Elland Road through Anthony Gordon. Expecting Everton to hold a lead has become a fool's game.
Luis Sinisterra's leveller means that since Frank Lampard's first league game in charge of Everton in February, only Leicester (16) and Wolves (14) have dropped more points from winning positions than the Toffees (13).
Leeds would have seen this as an opportunity to put three more points on the board, but at least their unbeaten run at home continues. They have earned eight points from their last four league games at Elland Road (W2 D2), which is as many as they had mustered from their previous 11 (W2 D2 L7).
Will Gordon stay with Everton beyond Thursday's transfer deadline, or could the links to Chelsea see him move on? He has now scored two goals in his last two Premier League games, having netted just four in his first 52 appearances. His last two strikes have been away from home, with each of his first four coming at Goodison Park.