There are plenty of intriguing fixtures to get excited about this weekend.
Tottenham host Bournemouth before Manchester City travel to Southampton later on Saturday, with the weekend's big tie coming at Old Trafford between Manchester United and Chelsea.
There are a few standout candidates for inclusion in your fantasy team, but who should you draft in?
Joel Robles - Burnley are pretty toothless away from home, so Robles could easily register points for a clean sheet on Saturday.
Wayne Hennessey - Sam Allardyce's side are now a solid unit at the back and Hennessey will hope to continue his run of four clean sheets in six games.
Emiliano Martinez - He may be a cheap option in goal but if Arsenal keep conceding goals, then there's no point in selecting Martinez.
Thibaut Courtois - The Belgium international has arguably been the best goalkeeper this year but he hasn't kept a clean sheet in the league since January.
Gareth McAuley - It's basically a given that a West Brom defender will score against Liverpool on Sunday, given the Reds' poor defence, and McAuley is one of the Baggies' top-scorers.
Maya Yoshida - Southampton have looked solid in recent matches, keeping two clean sheets in their last three games, and Yoshida even managed a goal during the win over Crystal Palace.
Adam Smith - The full-back was unfortunate to net an own goal against Chelsea last time out but his side will likely concede a few when they travel to Tottenham in Saturday's early kick-off.
Sam Byram - The former Leeds man had one of his best West Ham games against Swansea last weekend but picked up an ankle injury and is a doubt for the trip to Sunderland.
Dele Alli - The return of Harry Kane may help to bring out even more from Alli, who has 13 league goals in his last 15 games.
Wilfried Zaha - The 24-year-old is finally delivering some goals and assists to match his exciting potential, grabbing three assists and a goal in his last three games.
Alexis Sanchez - Arsenal's season is in danger of petering out and Sanchez's lack of form isn't helping, with the Chilean without a strike in his last three games.
Etienne Capoue - A smart choice at the beginning of the season due to his advanced role, Capoue's form in the second half of the campaign has been disappointing.
Harry Kane - Kane made his comeback from an ankle injury last weekend and will hope to get back to scoring ways when Spurs host Bournemouth.
Romelu Lukaku - The leading scorer in the Premier League now has 23 goals in the competition after bagging a brace in the 4-2 win over Leicester.
Jermain Defoe - Sunderland look set for the drop mainly due to Defoe's lack of form in front of goal recently, with the England international without a goal since February.
Alvaro Negredo - Middlesbrough have been tame going forward this year and that inefficiency hasn't helped Negredo, who has seven Premier League goals for Steve Agnew's side.