With a 20th league title virtually in the bag and no more European distractions, Manchester United manager Alex Ferguson is challenging his side to push for a Premier League points record.
United visit Sunderland on Saturday when victory would open up an 18-point lead, at least until second-placed Manchester City host Newcastle United later
Tottenham visit mid-table Swansea City, hoping that Welshman Gareth Bale, who scored at the Liberty Stadium for his country in midweek, can re-ignite their Champions League challenge.
Arsenal, who are four points behind with a game in hand, host joint-bottom Reading, for whom Nigel Adkins takes charge for the first time since being appointed manager.
Chelsea travel to Adkins' old club Southampton looking for a third consecutive league victory. Sixth-placed Everton, whose own top-four hopes were revived by their victory over City, are at home to Stoke City.
Wigan Athletic can boost their chances of remaining in the top flight when they take on Norwich City. Victory would lift them out of the bottom three above Aston Villa who are at home to Liverpool on Sunday.
Click on the games for full team news, manager quotes and match stats.
(15:00 unless stated)
Arsenal will be without England duo Jack Wilshere (ankle) and Theo Walcott (hip/thigh). Former Gunner Stuart Taylor is likely to again deputise for goalkeeper Adam Federici for the visitors.
Captain Vincent Kompany is Manchester City's chief concern. Newcastle boss Alan Pardew is facing a fresh injury crisis as Cheick Tiote, Mathieu Debuchy, Davide Santon, Massadio Haidara, Tim Krul, Fabricio Coloccini and Hatem Ben Arfa are all missing.
Adam Lallana, Luke Shaw and Jos Hooiveld are all dealing with knocks for the home side. John Terry is available for Chelsea but manager Rafael Benitez will select with one eye on Monday's FA Cup quarter-final.
Chico Flores is set to return to the Swansea squad after seven weeks on the sidelines. Tottenham star Gareth Bale is fit and winger Aaron Lennon (hamstring and groin) and centre-back Michael Dawson (hamstring) have recovered from their respective injuries and are likely to start.
West Ham captain Kevin Nolan has recovered from a toe injury and Joe Cole returns following a month-long hamstring injury lay-off. Midfielder James Morrison is West Brom's major fresh injury concern of the trip to Upton Park.
Wigan boss Roberto Martinez is hoping striker Callum McManaman will be fit and must decide whether to recall goalkeeper Ali Al Habsi and captain Gary Caldwell after two wins in a row without them. Norwich manager Chris Hughton has confirmed third choice keeper Lee Camp will start in goal.
Everton could welcome back goalkeeper Tim Howard and defender Phil Jagielka. Stoke have Robert Huth back available.
Aston Villa manager Paul Lambert will welcome back a quartet of players but has fitness concerns over two others. Liverpool have goalkeeper Jose Reina and defender Jamie Carragher fit again.
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