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The relentless Blues initially extended their early lead at the summit to six with a straightforward 3-0 win at Leicester that saw goals from Antonio Rudiger, N’Golo Kante and Christian Pulisic.
On Sunday, Manchester City beat Everton 3-0 to move above Liverpool into second place.
Ole Gunnar Solskjaer has been sacked by Manchester United after a humiliating 4-1 loss at Watford, while Steven Gerrard and Dean Smith secured wins in their first matches in charge at Aston Villa and Norwich respectively.
West Ham’s impressive run came to an end at Wolves, while there were two six-goal thrillers between Burnley and Crystal Palace and Newcastle and Brentford.
Tottenham beat Leeds 2-1 in the final game of the weekend.
Premier League table 2021/22
Premier League 201/22 fixtures, gameweek 12
All times GMT
Saturday, November 20
1230) Leicester 0-3 Chelsea
1500) Aston Villa 2-0 Brighton
1500) Newcastle 3-3 Brentford
1500) Norwich 2-1 Southampton
1500) Wolves 1-0 West Ham
1500) Burnley 3-3 Crystal Palace
1730) Liverpool 4-0 Arsenal
Sunday, November 21