West Ham are deprived of loan signing Andy Carroll due to a hamstring injury but fellow new recruit Yossi Benayoun could make his debut after signing for the season on loan from Chelsea.
Arsenal welcome back Wojciech Szczesny as they attempt to extend their run of clean sheets to four in four games. Southampton could hand a debut to Uruguay international Gaston Ramirez following his shock move from Bologna.
Villa boss Paul Lambert will have three deadline-day arrivals in his squad with Christian Benteke, a £7 million capture from Genk, the pick of the bunch. Swansea's eye-catching signings Pablo Hernandez and Ki Sung-yueng will be on the bench.
Dimitar Berbatov is expected to make his first start for Fulham while fellow striker Bryan Ruiz is rated at 50/50. Romelu Lukaku has recovered from an ankle injury and is fit to feature for the Baggies, who have made an impressive start to the season under Steve Clarke.
Darren Fletcher has been included in the Manchester United squad as he continues his fight against illness, while Robin van Persie and Shinji Kagawa are both available despite suffering knocks on international duty.
Chelsea defenders John Terry and Ashley Cole have both shrugged off ankle injuries to face Anton Ferdinand for the first time since Terry was cleared of racially abusing the QPR defender in July. Ferdinand himself is fit after recovering from a shoulder injury.
Michael Owen hopes to make his debut for Stoke after joining the club on a free transfer. The visitors are hopeful that striker Sergio Aguero will be able to feature after recovering quickly from a knee injury.
Liverpool will hope Luis Suarez is fit after travelling to Uruguay for international duty as the Reds are desperately short of options in attack. Joe Allen has recovered from illness though and is ready to start in midfield.
Andre Villas-Boas's big decision is whether to hand a debut to deadline day signing Hugo Lloris, who is unhappy that his new manager suggested Brad Friedel would remain number one in the short term. Clint Dempsey will make his debut.
Newcastle have been hit by an injury to goalkeeper Tim Krul which rules the Dutchman out for three games. Everton also have injury problems with Darron Gibson absent for up to five weeks and Steven Pienaar a doubt.
- Andy Carroll
- Yossi Benayoun