The trailer for the series - which sees a number of names including Harry and Winfrey open up about their mental health struggles - dropped on Monday ahead of its premiere this Friday, May 21, on AppleTV+.
Harry and Oprah are producers of the series - which was shot by four-time BAFTA Award-winning director Asif Kapadia who was behind Amy, the film about singer Amy Winehouse.
Meghan, 39, makes two short appearances in the trailer. In one, she stands behind her husband wearing a statement T-shirt reading “raising the future.” The t-shirt female-run small business Mère Soeur - a brand which the Duchess has worn before.
The other is previously seen footage of Meghan, who is pregnant with her second child - a girl, with the couple’s son Archie, two.
The docuseries also features singer, songwriter, and actress Lady Gaga, actress Glenn Close, Syrian refugee Fawzi, DeMar DeRozan of the NBA’s San Antonio Spurs, author and counselor Ambar, and many others.
Some 14 medical experts are also interviewed throughout the series to share their insights about mental health and treatment.
Lady Gaga said she wanted to share her mental health story as: “I have been through it and people need help.”
In the trailer, Harry says: “To make that decision to receive help is not a sign of weakness, In today’s world, more than ever, it is a sign of strength.”
Archive footage of a young Harry, now 36, at the funeral of his mother, Princess Diana, is also in the trailer.
Speaking on the podcast Armchair Expert with Dax Shepard, Harry said: “There is no blame.
“I don’t think we should be pointing the finger or blaming anybody, but certainly when it comes to parenting, if I’ve experienced some form of pain or suffering because of the pain or suffering that perhaps my father or my parents had suffered, I’m going to make sure I break that cycle so that I don’t pass it on, basically.
“It’s a lot of genetic pain and suffering that gets passed on anyway so we as parents should be doing the most we can to try and say ‘you know what, that happened to me, I’m going to make sure that doesn’t happen to you’.”
Harry also revealed as a young man he did not want to be a working royal: “I was in my early 20s and it was a case of, ‘I don’t want this job. I don’t want to be here. I don’t want to be doing this.’”
The Prince of Wales ignored questions about the Duke of Sussex who has suggested Charles’ parenting left him with “genetic pain and suffering”.
Charles ignored questions and carried on walking when asked about his son’s comments by a BBC reporter as he arrived for a visit to a family business in Cardiff hours after the podcast was broadcast.