The reigning Super Bowl champions will make the trip to New York state to start their defence in the 2022 campaign curtain raiser.
Before a ball is kicked however, both teams will pay tribute to the late monarch, Britain's longest-reigning sovereign at the time of her passing at the age of 96.
"Everyone at NFL UK is deeply saddened to hear of the passing of Her Majesty The Queen, Elizabeth II," read an official message posted to social media by the league.
"Our thoughts and deepest sympathies are with The Royal Family. We join all those mourning the loss of Her Majesty."
The NFL is due to hold three games in London this year as part of their International Series, with the first to come in week four between the Minnesota Vikings and the New Orleans Saints at Tottenham Hotspur Stadium.