Misano plays host to the San Marino round of the series and, while it was the scene of Rea's first WSBK win back in 2009, his last two visits have not been so kind to him.
Last year the Northern Irishman sustained a serious wrist injury during warm-up, putting him out for three months, and the 25-year-old is keen to move on from that disappointment.
He heads to Italy in good form, occupying fourth place in the standings after impressive outings at Donington and Miller Motorsports Park.
"The last few races have been pretty good really, so we’re hoping to be able to take that positive momentum forward into the Misano round this weekend," Rea said.
"There’s a fantastic atmosphere in the team and the recent results have given everyone a lot of motivation to keep it going. It’s important that we continue to move forward because there are still a lot of areas where we need to improve.
"But there are a lot of positives, too, especially with the electronics, where the crew and my data engineer, Arlan Holterman, have been working really hard.
"The last couple of visits to Misano have not been good, but I don’t want to be dwelling in the past because we’ve got the bike working really well now – as we’ve shown at Donington and Miller, where it wasn’t so good before.
"I love going to Misano, though; I got my first World Superbike win there, and the beach and the food are great, of course. It’s also the last chance this season to meet the passionate Italian fans, and that’s always a special treat."
Team manager Ronald ten Kate said: "We’ve had our ups and downs at Misano in recent years so for sure it’ll need a lot of work to get it right this year.
"However, after the results at Miller, we know that the Fireblade package is a lot more competitive than last year so we’re really looking forward to the challenge."
The weekend's action kicks off at the Misano World Circuit on Friday with free practice and the first qualifying session before Sunday's races.