Real Madrid are set to be without Gareth Bale for three to four weeks meaning that he will miss the crucial Champions League semi-final against city rivals, Atletico, as reported by AS.
The Welsh forward only recently recovered from an injury in time to start in Sunday's El Clasico, but after just 35 minutes, the 27-year-old had to be taken off with a suspected calf injury.
Now, Zinedine Zidane is left with the prospect of being without one of his star men for perhaps the most crucial part of the season - it is Bale's 17th injury in the famous white shirt.
The French manager says he believed the Welsh forward was 100% fit for the game against Barcelona, a match which Los Blancos went on to lose 3-2 courtesy of an injury-time winner from Lionel Messi.
However, given the recent form of Bale, many Madridistas may not be too disappointed with his absence from the team.
Both Isco and Marco Asensio have featured in recent weeks and have arguably performed to a higher standard than the former Tottenham star.
Goalless in his last seven appearances for Los Blancos, Bale has looked a pale shadow of the fearsome attacker we saw for large periods of last season.
Injuries this campaign have hampered his form with rumours suggesting that Florentino Perez could be keen on selling him this summer.
Madrid have two La Liga matches prior to their meeting with Atletico with an away trip to Deportivo on Wednesday followed by a home fixture against Valencia on Saturday.
Bale will miss both fixtures in what could be the most decisive period of the season for Zidane's silverware chasing squad.