Both AFC East sides boast a 2-0 record after the opening two weeks of the campaign, though the story of their triumphs has been vastly different.
Outscoring their opponents 72-17 resulted in a +55 point differential for the Bills that stands as their second-best in franchise history at this stage of a season (+63 points after the first two games in 1981).
Miami, meanwhile, rallied against the Baltimore Ravens last Sunday to incredibly overcome a 21-point fourth-quarter deficit to win.
It marked only the sixth occasion since 1925 in the NFL where a team has overturned such a margin in the fourth quarter.
Sunday's match-up will see the top-three players for receiving yards take to the field, with Tyreek Hill leading the league with 284 ahead of the Bills' Stefon Diggs (270) and team-mate Jaylen Waddle (240).
Hill's 19 receptions have included two touchdowns, while Diggs' 20 catches have resulted in four TDs – more than any other NFL player.
Both teams will certainly feel comfortable in targeting those players, with Tua Tagovailoa throwing six TDs last week, including four in the fourth quarter.
Josh Allen, meanwhile, has thrown at least two TD passes in each of his eight career appearances against the Dolphins. That is the longest such streak achieved against a single team in Bills history.
Such an array of offensive talent may flip the pressure onto the defenses, though the Bills will feel confident of putting pressure on Tagovailoa having secured nine sacks in the opening two games – the second-highest in the NFL behind only the Tampa Bay Buccaneers (10).
The Bills also hold the historical edge, boasting seven straight wins against the Dolphins which represents their best-ever sequence against Miami.