Spurs reached the final in Madrid last season but have made an underwhelming start to this season’s tournament, drawing with Olympiacos and then being hammered at home by Bayern Munich.
But their confidence was boosted by beating today’s opponents Red Star 5-0 at home at the end of October – although the Serbian side are likely to be a different proposition in their own backyard. Follow live coverage below, after updates from Lokomotiv vs Juventus.
When is it?
Kick-off is at 8pm GMT on November 6.
How can I watch it?
The match will be aired live on BT Sport 2, with coverage beginning at 7pm.
Subscribers can also watch the game via the BT Sport app, or online via the BT Sport player.
Red Star Belgrade 15/4
Red Star are a far tougher proposition at home in Serbia and have not lost a domestic game in more than a month. It could be an edgy night in Belgrade, but Tottenham should be able to battle to three points.
2-1 to Tottenham is our prediction.