Andy Madley will take charge of Albion's game at Liverpool.
His video assistant will be Simon Hooper.
Madley last refereed the Seagulls when they beat Manchester United 4-0 last season.
He has taken charge of 17 Albion games since 2013 and their only defeat in that time came when they were shocked 3-1 by Lincoln City in the FA Cup.
Madley last reffed at Anfield when Liverpool beat Cardiff in an FA Cup tie in February.
The full officiating team is as follows.
Referee: Andy Madley. Assistants: Derek Eaton, Steve Meredith. Fourth official: Tony Harrington. VAR: Simon Hooper. Assistant VAR: Darren Cann.