Sudeikis was joined by Fred Armisen as Giuseppe, the Kenny G-esque saxophone player, with Kenan Thompson taking on his traditional role as Diondre Cole, the host of the BET talk show.
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The trio were joined by Dune star Oscar Isaac, model Emily Ratajkowski and Nicholas Braun, who was not Lindsey Buckingham in a Cousin Greg costume.
It marks the latest take on the classic skit – the first since April 2020, when Brad Pitt, as Dr. Anthony Fauci, was joined by Charles Barkley and DJ Khaled featured in a Zoom/pandemic take.
Prior to that, the last What Up With That was in December 2012, featuring a curse word-laden Samuel L. Jackson.
Check out the skit above.
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