The American, who won the title in 2003, 2004, 2005 and 2007, and reached finals at Wimbledon in 2004, 2005 and 2009, is now fully fit after a difficult year with injuries.
He scored an impressive win in Miami over Roger Federer last week and can't wait to return to London.
"I love coming back to the Queen's Club," said Roddick. "There's so much history there and it's one of my favourite tournaments on the Tour. It's hard to believe I've won a tournament as strong as the AEGON Championships four times and I'd love to win it again."
A hamstring injury and an ankle problem interrupted his Australian Open campaign and prevented him from building the momentum he was looking for in February, but Roddick is now looking forward.
“I feel like something good is coming,” said Roddick, who won the US Open and became world number one in 2003.
He joins Andy Murray, Jo Wilfried Tsonga and Juan Martin Del Potro as early entrants in the field.