Rodriguez, who finished third in the Vuelta a Espana behind Spanish compatriots Alberto Contador and Alejandro Valverde, is nine points behind Briton Bradley Wiggins in the standings.
The winner will take 100 points, with 80 for second, 70 for third then 60, 50, 40, 30, 20, 10 and 4 down to a 10th-place finish.
'Purito' Rodriguez finished third in the Italian classic last year.
Giampaolo Caruso, Vladimir Gusev, Alexander Kolobnev, Alberto Losada, Daniel Moreno, Luca Paolini, Joaquim Rodriguez, Yuriy Trofimov
- Joaquim Rodriguez
- Alejandro Valverde
- Alberto Contador
- Alberto Losada