The 23-year-old's 16 K's was the most ever by a Braves pitcher in a nine-inning game, bettering John Smoltz's previous record of 15, coming in only his 17th career Major League start.
Strider, who had 79 strikes from 106 pitches, allowed two hits and did not walk a batter, with a mix of fastballs and sliders across eight innings.
The 16 strikeouts were the most in the majors since Walker Buehler had 16 against the Rockies in June 2019.
"I lost track after five [innings]," Strider said about his strikeouts count. "I came out of the game and Kyle [Wright] was telling me something about John Smoltz or whatever. It didn't make any sense.
"It's pretty wild, the guys who've thrown in this organization, it's a long, incredible list. I'm just grateful to be here and having success."
Austin Riley and Michael Harris II hit solo home runs for the Braves, who improve to 81-51 to be three games behind the New York Mets (84-48) in the National League East.
Kershaw shakes off the rust in Dodgers defeat
Clayton Kershaw returned from the injured list with an efficient display but he could not inspire the Los Angeles Dodgers to victory, losing 5-3 to the New York Mets.
After a rusty start, Kershaw had six strikeouts across five innings, allowing one hit, one earned run while walking three batters.
Francisco Lindor was the hero with a tying RBI double in the sixth inning before scoring the go-ahead run with a sacrifice fly in the seventh, while Edwin Diaz struck out Gavin Lux to escape a jam in the eighth.
Red Sox rally wth Refsnyder career-first walk-off
Rob Refsnyder's single clinched a walk-off win for the Boston Red Sox who rallied with a four-run ninth inning to win 9-8 over the Texas Rangers.
The Red Sox, who had been behind 8-3 in the eighth, trailed 8-5 entering the ninth with Rafael Devers hitting a two-run double to narrow the deficit before Kike Hernandez's RBI single tied it up.
Refsnyder walked it off for the first time in his career with a line shot that drove home Devers.