Fly-half Freddie Burns scored 20 points, including a first-minute try, and there were also touchdowns for Marland Yarde, Kyle Eastmond, Christian Wade and Billy Twelvetrees as the Baa-baas offered only token resistance.
The Barbarians now head to Hong Kong for an appointment with the British and Irish Lions next Saturday.
Late tries from replacement hooker Schalk Brits and full-back Elliot Daly were no consolation for a team outplayed in every department.
England, meanwhile, are braced for Test matches against Argentina in Salta and Buenos Aires, and head coach Stuart Lancaster will feel satisfied with his players' work, despite relatively weak opposition.
The groundwork was done up front, where prop Dave Wilson, lock Joe Launchbury and number eight Ben Morgan delivered performances of considerable stature.
And that meant an exciting England back division, well marshalled by Burns and full-back Mike Brown, had opportunities to showcase some of the talent that could serve England well at World Cup 2015 on home soil.
The only disappointment for Lancaster and his coaching staff will be the two tries England conceded, but it was otherwise a comfortable 80 minutes that also looks to have passed injury-free.
England made a blistering start in glorious conditions, scoring from their first attack inside 45 seconds after Barbarians skipper Mike Tindall conceded turnover ball.
Possession was then moved wide quickly to Yarde, who broke a couple of weak tackles and delivered an inside pass that Burns collected for an all-too-easy opening try.
Burns converted and then kicked two penalties for a 13-0 lead after 12 minutes as the Baa-baas compounded their lack of attacking fluency by making some poor decisions.
And the invitational team also encountered considerable problems in the scrums, where England's front row of Alex Corbisiero, Rob Webber and Wilson made hay in the sunshine and meant their opponents had no platform to play off.
Burns completed his penalty hat-trick in the 25th minute, and although their opponents showed glimpses of attacking potential through centre Casey Laulala's silky running skills, England trooped off 16 points clear at half-time and in complete control.
And they extended that advantage within five minutes of the restart when Yarde surged past Laulala just inside the Barbarians' half and then turned on the after-burners to claim a superb solo try.
Burns again converted, and with a 23-point lead Lancaster began ringing the changes, sending on Haydn Thomas, Henry Thomas, Kearnan Myall and Billy Vunipola, but it was a fifth substitute - Eastmond - who posted England's third touchdown.
With gaps opening up all over the pitch, England looked to keep pace and width on the ball, and Wasps flyer Wade capped a memorable week for him by leaving his opposite number Takudzwa Ngwenya floundering.
The newly-crowned Rugby Players' Association players' player of the year and young player of the year did not disappoint his many admirers in the crowd by delivering a try they demanded.
And Twelvetrees followed him over the Barbarians' line as England hit 40 points without being seriously tested.
- Sports & Recreation
- Billy Twelvetrees
- Freddie Burns
- Marland Yarde
- Kyle Eastmond
- Christian Wade