Centre D'Arcy, blindside flanker Mahony and replacement back Earls picked up injuries in the 30-22 win over defending champions Wales last Saturday.
England, who began their campaign with a 38-18 win over Scotland, have not beaten Ireland in Dublin since 2003, the last time they won the grand slam.
Ireland - 15-Rob Kearney, 14-Craig Gilroy, 13-Brian O'Driscoll, 12-Gordon D'Arcy, 11-Simon Zebo, 10-Jonathan Sexton, 9-Conor Murray, 8-Jamie Heaslip (captain), 7-Sean O'Brien, 6-Peter O'Mahony, 5-Donnacha Ryan, 4-Mike McCarthy, 3-Mike Ross, 2-Rory Best, 1-Cian Healy.
Replacements: 16-Sean Cronin, 17-David Kilcoyne, 18-Declan Fitzpatrick, 19-Donncha O'Callaghan, 20-Chris Henry, 21-Eoin Reddan, 22-Ronan O'Gara, 23-Keith Earls.
- Sports & Recreation