Uncapped trio Jack Nowell, Anthony Watson and Luther Burrell could start in the backline named for Saturday's showdown at the Stade de France.
Jonny May has only one Test appearance under his belt and is challenging Nowell and Watson for a place on the wings.
Lancaster insists that if he believes they are ready for one of the Six Nations' biggest fixtures, they will be thrown into battle.
"I've never shied away from giving people without much experience opportunities. At some point you have to do it," Lancaster said.
"I've never been afraid of giving people opportunities - this time two years ago I selected seven players with no caps for Scotland away.
"There is a balance to strike, but I've always been reasonably confident to pick inexperienced players if I feel they're ready.
"For me it's exciting to give young players opportunities, particularly if they've been performing well and showing it consistently at their clubs.
"At some point you have to make the step. There will be some people with less experience in the France game."
Team selection will be finalised after training on Tuesday and announced on Thursday morning, before England depart for Paris hours later.
"You can watch as many games as you like, but it's only when you coach the players and talk to them one on one that you get a feel for whether they have the temperament to play in a game like this," Lancaster said.
"I trust my instincts in that regard. Last week was great to have that time with the players. Today and tomorrow we'll finalise it."
- Sports & Recreation
- Luther Burrell
- Jack Nowell