It includes skipper Brett Hodgson, one of three Warrington players who will be appearing on their home ground, and Wigan's goalkicking winger Pat Richards, who represents Ireland through his Dublin-born father.
St Helens second rower Sia Soliola is the Exiles' only ever-present going into the fourth match between the sides while six players are set to make their debuts, including Hull KR half-backs Michael Dobson and Travis Burns.
Dobson, who has been unfortunate to miss out in the previous two years, was set for a reunion with his old Rovers half-back partner Blake Green, now at Wigan, but he is sidelined through injury.
"It's my first one so I'm looking forward to it," Dobson said. "I was 19th man for the second game last year.
"It's disappointing for Blake but it gives Travis the opportunity to play and hopefully we both do well.
"It is going to help having played at club level together. We've both been injured at different times so we're still a work in progress. We're getting there but we're definitely not the finished article."
The other new faces are forwards Mickey Paea (Hull KR), Zeb Taia (Catalan Dragons), Harrison Hansen (Wigan) and Chris Bailey (London Broncos). St Helens second rower Willie Manu and Widnes full-back Rhys Hanbury were the players omitted by coach McClennan from his 19-man squad.
Exiles team: B Hodgson (Warrington, Aus, capt); J Monaghan (Warrington, Aus), S Menzies (Catalan Dragons, Aus), J Moon (Leeds, Aus), P Richards (Wigan, Ire); T Burns (Hull KR, Aus), M Dobson (Hull KR, Aus); K Leuluai (Leeds, Samoa), H L'Estrange (Bradford, Aus), T Puletua (St Helens, Samoa), S Soliola (St Helens, Samoa), T Waterhouse (Warrington, Aus), H Hansen (Wigan, Samoa).
Interchange: L Hohaia (St Helens, NZ), M Paea (Hull KR, Tonga), Z Taia (Catalan Dragons, Cook Islands), C Bailey (London Broncos, Aus).
- Michael Dobson
- Travis Burns