The Senegal international opened the scoring in the 228th Merseyside derby before limping off the pitch mid-way through the second half.
Speaking after his side’s victory, Jürgen Klopp, the Liverpool manager, suggested that Mane’s injury was not too serious but believes he will not be available for Wednesday’s match at Anfield.
“Today we played a really good game. Nearly everything was perfect, we win it, the performance was good, then we lose Sadio Mane,” he said.
“When I saw him in the dressing room, it didn’t look like he’ll be ready for Wednesday.
“We will see, hopefully it’s not that serious, but of course it’s not nothing and that makes our life not easier, I would say,” Klopp added.
When questioned on the specifics of Mane's injury, Klopp refused to speculate and said: “Obviously he has pain and it didn’t look like it’s only a knock or a muscle or something, but we have to wait.
“When I came in I was looking for him immediately and I saw him on the bed. He’d already had treatment, and it didn’t look like he felt really comfortable.”
Divock Origi replaced Mane in the 57th minute and subsequently scored Liverpool’s third goal, adding to Philippe Coutinho’s first-half strike.
Klopp is currently without Adam Lallana, one of Liverpool’s stand-out performers this season, after he picked up a thigh injury while on international duty with England.
Captain Jordan Henderson and Daniel Sturridge also missed Saturday’s win over Everton, with foot and hip problems respectively.