Lattimore, 26, last played in the Saints' Week 5 victory against the Seattle Seahawks, where he suffered an abdomen injury that cost him 10 weeks of action.
He will return to a Saints team who have struggled to a 6-9 record, but are riding a two-game winning streak and still have everything to play for, sitting only one game behind the 7-8 Tampa Bay Buccaneers in the race for the NFC South with two fixtures remaining.
Lattimore will be joined by a second big inclusion for the Saints as first-round draft pick Chris Olave is also expected to make his way back from a hamstring injury he suffered in Week 15 against the Atlanta Falcons, according to NFL.com's Ian Rapoport.
Olave, a 22-year-old receiver, has 940 receiving yards this season – 460 more than any other Saints player.
The Eagles are expected to be without starting quarterback and MVP candidate Jalen Hurts for the second week in a row, although he has now returned to the practice field.