Wilson has not played since suffering a meniscus tear and bone bruise in his right knee in the Jets' preseason opener, with veteran QB Joe Flacco stepping in during his absence.
Jets head coach Robert Saleh confirmed Wilson would start ahead of Flacco on Sunday, barring any unforeseen setbacks prior to the game.
"If all goes well this week, absolutely," Saleh said when asked about starting Wilson. "He's very comfortable. He's in a great mental state. Everyone is comfortable with where he's at physically."
Wilson, who was second pick overall in the 2021 NFL Draft, reiterated that he was physically ready.
"I'm 100 per cent, I'm ready to go," Wilson said. "The biggest thing is you haven't played ball in a little bit, you've been trying to replicate as much as possible, so I'm just going to have fun with this process and getting back in and just giving it my best."
Wilson's latest injury was on the same knee that he sprained last season, causing him to miss four games. The Jets quarterback insisted he would not alter his playing style to protect the knee.
"I'm full go. I'm going to play ball how I can," Wilson said. "If somebody comes up, [I'll] make somebody miss, get out on the edge, extend plays when I need to, hang in the pocket. I'm playing exactly how I should be."
In his rookie season, Wilson started 13 games, completing 213 of 383 attempts for 2,334 yards and nine touchdowns with 11 interceptions. He was sacked 44 times.