Salzburg will have to do what no other Austrian side has done before at Milan to qualify for the Champions League knockout stages, while Jude Bellingham has his eyes on an achievement managed by only two players previously.
The Rossoneri need only a point from the game at San Siro and the historical facts suggest they will achieve their aim to make it out of Group E.
For Bellingham, he can put his name in the record books alongside former team-mate Erling Haaland and Kylian Mbappe by scoring for Borussia Dortmund at Copenhagen.
There is plenty to play for as the Champions League group stage wraps up on Wednesday, and Stats Perform has trawled through the data to shine a light on the most interesting angles.
Milan v Salzburg
With a win, Salzburg will advance to the knockout stages for the second consecutive season after never making it out of the group stage previously.
They will need to defy the odds on their trip to Milan, where the Italian side are undefeated in home fixtures against Austrian opponents in the competition (W4 D1), while averaging 3.8 goals per game.
Salzburg have never beaten Milan in their three previous Champions League meetings, but after losing the first two, they collected their first point with a 1-1 draw in this campaign's reverse fixture.
While Olivier Giroud became the oldest player in Champions League history to reach 20 goals (36 years old) during Milan's win at Dinamo Zagreb last time out, Salzburg boast the youngest starting XI in the competition with an average age of 22 years and 279 days.
Shakhtar Donetsk v RB Leipzig
Shakhtar have only won one game in the group stage, but sit three points behind second-placed. A win would see them through to the knockout stages for the third time in the past four seasons.
The reverse-fixture was a memorable one for Shakhtar and exciting young winger Mykhailo Mudryk, who showed why he is so in-demand with a goal and two assists in a 4-1 away win.
Unfortunately for the Ukrainian side, that was their only victory from their past 12 Champions League matches (D6 L5).
Meanwhile, Leipzig have found some form in the competition, with back-to-back victories against Celtic before making it three wins in a row when they beat Real Madrid 3-2.
Manchester City v Sevilla
City are eyeing an undefeated group stage when they host Sevilla, having only conceded one goal in total from their five games until this point.
English sides have given Sevilla trouble for years now, with their last Champions League win over a Premier League team coming back in 2007 against Arsenal.
If Jorge Sampaoli's side are to stand any chance of a shock win, they will need to pay special attention to Jack Grealish, who has impressed in the group stage with 10 chances created from open play, the most in Pep Guardiola's squad.
Maccabi Haifa v Benfica
If Juventus can salvage even a draw in their clash with Paris Saint-Germain, then Benfica will be able to win Group H by defeating Maccabi Haifa.
It has been a special run of form for Benfica, who for the first time since 1990 have gone six Champions League games without a loss (W3 D3).
Maccabi will have their backs against the wall, as only Malmo have a worse winning percentage (17 per cent) than their 24 per cent among teams to have played at least 15 Champions League games.
Also working in Benfica's favour is manager Roger Schmidt's record in the competition. Between his time with Bayer Leverkusen (2014-2017) and Benfica in this campaign, his run of 13 games unbeaten is the most by any active manager qualified for this season's Champions League.
Juventus v Paris Saint-Germain
5 - Juventus are looking to avoid becoming the second Italian side to ever lose five matches in a Champions League group stage, after Roma in 2004-05.
6 - Paris Saint-Germain's Kylian Mbappe has six goals in the group stage. With one more he can tie Christopher Nkunku (last season) for the most by a French player in a single group stage, while with two more he can tie Zlatan Ibrahimovic's club-record of eight in 2013-14.
Copenhagen v Borussia Dortmund
60 - Despite Copenhagen still being without a win in Group G, they have kept a clean sheet in 60 per cent (nine-of-15) of their Champions League home games – the best ratio of any team with at least 10 appearances.
3 - With a goal, Bellingham can become just the third teenager to ever score in all three away games in a Champions League group stage, following Mbappe (2017-18) and Haaland (2019-20).
Chelsea v Dinamo Zagreb
10 - Chelsea are undefeated in their past 10 group stage games in the Champions League dating back to September 2019 (W6 D4). Over that period, they are averaging 2.3 goals per game.
10 - Along with City's Grealish, Chelsea's Mason Mount is the only other Premier League player from this Champions League campaign to tally at least 10 shots and 10 chances created.
Real Madrid v Celtic
20 - Since the beginning of last season's Champions League, no player has been involved in more open-play sequences that have resulted in a goal than Real Madrid's Vinicius Junior (20).
14 - Celtic's Matt O'Riley has attempted the most shots in the Champions League this season without scoring, with no goals from his 14 shots.