Jurgen Klopp‘s side came unstuck against Napoli at Anfield, meaning if the Italian side defeat Genk and Liverpool suffer defeat against a dangerous Salzburg side, the holders will be relegated to the Europa League via the head-to-head rule.
Salzburg pushed Liverpool all the way in the reverse fixture, coming back from a three-goal deficit before Mohamed Salah secured a 4-3 victory.
Liverpool have taken the chance to rest a number of key players in recent weeks, with Sadio Mane sitting out their 3-0 win against Bournemouth on the weekend.
Here is everything you need to know about the game:
What time is kick-off?
The match starts at 17.55 on Tuesday 10 December.
How can I watch it?
The match will be broadcast live on BT Sport 3 and the BT Sport app.
RB Salzburg: Stankovic; Kristensen, Onguene, Wober, Ulmer; Mwepu, Junuzovic, Szoboszlai, Minamino; Daka, Haaland
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Lallana, Henderson, Wijnaldum; Salah, Firmino, Mane
Dejan Lovren is likely to miss out after picking up an injury during Saturday’s victory against Bournemouth, although Georginio Wijnaldum and Adam Lallana are expected to be available having missed out. Fabinho and Joel Matip remain long-term absentees.
Seydou Koita, Patrick Farkas and Antoine Bernede have been ruled out, although Salzburg’s goalkeeper Cican Stankovic should be available after recovering from a thigh injury.