Needing just a point to confirm their place in Qatar, it is also impossible to imagine Gareth Southgate’s side not winning in Serravalle. Indeed, England could not have asked for a more favourable final game with something riding on it.
Having put five past Albania at Wembley on Friday night, it seems reasonable to assume there will be rotation from Southgate given the level of the opposition, with Crystal Palace loanee Conor Gallagher recently drafted into the senior squad.
Still, with Harry Kane finally finding form by scoring an excellent hat-trick on Friday, perhaps keeping the Tottenham man in the starting XI could further his attempts to get back to his best.
Where to watch San Marino vs England
TV channel: The match will be televised on ITV, with coverage beginning at 7pm.
Live stream: Viewers in the UK will be able to watch the match online via the website or ITV Hub app.
You can also follow the action on Standard Sport with our LIVE match blog.