"Because I wasn't a huge star, no one came looking," said the actress, who lives with multiple sclerosis
In a wide-ranging interview with Glamour for the 2023 Women of the Year issue, the actress, 51, said her screen work slowed down significantly after making the 2004 superhero flick. (She also starred in its 2008 sequel, Hellboy II: The Golden Army.)
"I still feel like I never really hit my stride with acting because after Hellboy I was so sick that I really stepped away," said Blair, who revealed in 2018 that she was diagnosed with multiple sclerosis and has been in remission since 2021.
"And because I wasn't a huge star, no one came looking," she added.
Blair previously shared that she went undiagnosed for 40 years before learning she had the autoimmune disease, but had experienced symptoms of MS as early as 7 years old.
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Blair — who will receive Glamour's Daring to Disrupt Award, presented by Ally — told the magazine she "do(es) wonder, practically" how she'd approach a role now, sharing that she believes she could memorize lines.
“I think that’s the key with everything,” she continued. “Really get comfortable with yourself and it doesn’t matter if you falter, because you know where to pick yourself up again.”
She added, “I had to realize I do love acting. I really would love an amazing director to ever think there’s something for me."
The Legally Blonde actress also recalled the difficulty of MS flares over the years ahead of her diagnosis, including "pure exhaustion" following the birth of her now-12-year-old son Arthur, which was incorrectly attributed to things like labor fatigue and postpartum depression.
As for the jobs she was able to take, “I was forcing myself on a plane, and I was getting vertigo,” Blair said. “I would wake up, and I couldn’t move.”
And while that "was a very hard time in my life,” she told Glamour it was also "the catalyst to become who I am now.”
Blair recently spoke with PEOPLE in early October and gave an update on her health journey, saying "everything's great" and she's "still in remission."
“I do have things that will probably always be with me, dystonia and things that come and go that are a real phenomenon," said the Cruel Intentions actress. "But neurology is an interesting thing and it's fascinating to me.”
According to the National Institutes of Health, dystonia is a neurological movement disorder seen in MS that's characterized by involuntary muscle contractions that cause slow repetitive movements or abnormal postures that can sometimes be painful.
“I do get tired,” Blair added to PEOPLE. “That's the thing. It is hard. So we do have to remember to build in a rest day … because if mama goes down then we're down for a minute. But when I'm up, I'm doing it and I'm happy. I'm really happy.”
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