The 27-year-old midfielder grew up in the Juventus youth academy and has been a key figure for the side since 2006.
Manchester United have long been interested in Marchisio, but up until now he was considered to be off the market.
According to persistent Italian reports, the situation has changed with the arrival of Paul Pogba on a free transfer from Manchester United.
His sale for around £25m would help raise funds for the reinforcements Juve want in attack over the summer.
Among the targets are Carlos Tevez of Manchester City and Liverpool’s Luis Suarez.
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