Favourite Browne emerged at the start of the heavyweight fight with a flurry of spinning heel kicks but in throwing a mistimed straight right damaged his knee.
He sought to continue the fight but Brazilian Silva took advantage of the injury. A big right hand to the chin with Browne backed up against the cage allowed him to fall upon the American and deliver a flurry of punches that caused the ref to step in at 3.27.
A cagey Jake Ellenberger took a unanimous decision against Jay Hieron in a rematch of a 2006 fight which had been won by the latter. He was awarded it 29-28 29-28 29-28.
John Dodson set up a flyweight title challenge against Demetrious Johnson with a second-round stoppage of Jussier Formiga.
"This will be the fastest fight you've ever seen," Dodson said of his next fight against Johnson. "Make sure you rewind and watch it in slow motion."
In the other main-card bout, Justin Edwards submitted Josh Neer at 45 seconds of round one with a guillotine choke.
Antonio Silva bt Travis Browne - TKO round 1
Jake Ellenberger bt Jay Hieron - unanimous decision (29-28 29-28 29-28)
John Dodson bt Jussier Formiga - TKO round 2
Justin Edwards bt Josh Neer - submission round 1
Michael Johnson bt Danny Castillo - KO round 2
Mike Pierce bt Aaron Simpson - KO round 2
Marcus LeVesseur bt Carlo Prater - split decision (28-29 29-28 29-28)
Jacob Volkmann bt Shane Roller - submission round 1
Diego Nunes bt Bart Palaszewski - unanimous decision (30-27 29-28 30-27)
Darren Uyenoyama bt Phil Harris - submission round 2
- Sports & Recreation
- Martial Arts
- Jake Ellenberger
- John Dodson
- Jay Hieron