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Marcelo Bielsa’s side are seeking a top-half finish in their first campaign in the division since 2003/04, while the home team – having avoided relegation – are out to rise a couple of places in the standings before the season is over.
Both clubs are pursuing a third consecutive victory in the competition, with Leeds having comfortably defeated Burnley last time out after beating Tottenham, and Southampton having achieved wins against Crystal Palace and the relegated Fulham in their two most recent outings.
As such, Leeds are 10th in the table with two games remaining, while the Saints are 14th.
Here’s everything you need to know about the Premier League clash. We may earn commission from some of the links in this article, but we never allow this to influence our content.
When is it?
The game will kick off at 6pm BST tonight.
How can I watch it?
The match will air live on Sky Sports Premier League. Subscribers can also stream it live on the broadcaster’s website and SkyGo app.
If you’re not a Sky customer, you can grab a NOWTV Day Pass here to watch without a subscription.
What is the team news?
Southampton are still without the injured Will Smallbone and Ryan Bertrand, the latter of whom will leave the Saints at the end of this campaign. Jan Bednarek is also expected to miss out, as should Oriol Romeu.
For Leeds, winger Helder Costa could be absent here and in his team’s season-closer against West Brom.
Southampton: Forster; Walker-Peters, Stephens, Vestergaard, Salisu; Tella, Armstrong, Ward-Prowse, Redmond; Adams, Ings.
Leeds: Meslier; Ayling, Llorente, Struijk; Dallas, Phillips, Klich, Alioski; Harrison, Bamford, Raphinha.
Southampton 1-1 Leeds.