Southend moved to a point behind League Two leaders Crawley Town after a 3-0 win over 10-man Port Vale.
Mark Phillips' eighth-minute header put them ahead before Liam Dickinson nodded in the second just before the half-hour. Gareth Owen's close-range own goal, under no pressure at the far post, 10 minutes after the break made it 3-0 before the visitors' misery was compounded when Clayton McDonald was sent off for a second bookable offence as the Shrimpers went second.
Crawley were involved in the FA Cup, beating Bristol City of the npower Championship.
Oxford moved into seventh place after beating Aldershot 3-0.
Jon-Paul Pittman's eighth-minute header was doubled by Michael Duberry, and on the stroke of half-time Peter Leven completed the scoring.
Crewe made hard work of beating bottom side Plymouth at home as they twice let their opponents back into the game in the 3-2 win.
Two goals from Luke Murphy put Alex in control at half-time, but Adam Dugdale's foul on Warren Feeney allowed Simon Walton to score with a penalty five minutes into the second half.
The home side re-established their two-goal cushion just three minutes later through Ashley Westwood's spot-kick but even then they gave Argyle hope by allowing Matt Lecointe to score.
In the last minute Plymouth had Conor Hourihane sent off for a second bookable offence as Crewe held on.
Northampton moved three points clear of Plymouth at the bottom after a 2-1 win over Morecambe. Goals either side of half-time from John Johnson and Akwasi Asante ensured Kevin Ellison's 81st-minute goal counted for nothing.