Real Madrid (5-2) won 72-65 at Milanese outfit Emporio Armani (2-5) to move into a share of the lead in Group C as Sergio Rodriguez drained 19 points.
Due to the club's 2-0 record against Armani and Belgacom Spirou, it means they have guaranteed their spot in the next stage.
Barcelona moved to a perfect 7-0 record in Group D with a thumping 76-45 win in Poland against winless Asseco Prokom Gdynia (0-7). Victor Sada (17 points) and Erazem Lorbek (15) top scored for the Catalans.
Also in Group D Montepaschi Siena (5-2) and UNICS Kazan (5-2) are both now guaranteed progression into the Top 14 stage after wins over Union Olimpija (1-6) and Galatasaray Medical Park (3-6) respectively.
They were also victories for Fenerbahce, Bennet Cantù and Partizan Belgrade.