Wust, who won her maiden title in Heerenveen in 2007 and hasn't been beaten at the Championships for the past three years, won both the 500m and 3000m.
The 27-year-old four-time Olympic champion, two of which came at Sochi 2014 last month, now heads into the final two events with a massive 5.31 second lead over her nearest rival.
Russian Yuliya Skokova is that nearest rival in the 1500m and 5000m on Sunday after she placed second in the 500m and sixth in the 3000m on the opening day.
And it is more than likely that Wust will be part of a Dutch double on their own ice in Heerenveen with Koen Verweij the most consistent skater in the men's field.
The 23-year-old Olympic team pursuit champion from Sochi 2014 was second in both the 500m and 5000m for a lead of 0.81 over teammate Jan Blokhuijsen.
Blokhuijsen was seventh and first in the 500m and 5000m respectively with the 1500m and 10,000m to come on Sunday to decide who'll take gold.
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