Samuel, a first team All-Pro selection in 2021, was injured in the 49ers’ 44-23 loss to the Kansas City Chiefs last week. The dynamic playmaker played through the issue during the game, but did not practice at all this week.
Niners head coach Kyle Shanahan on Friday said he is hopeful Samuel can return for San Francisco’s November 13 game against the Los Angeles Chargers following a Week 9 bye.
"He's not good enough to go," Shanahan said. "The fact that he even had a chance hopefully means he'll be good with the week off and be ready for the next game."
Samuel has compiled 387 receiving yards and two touchdowns on 32 catches so far this season, while adding 138 rushing yards and a touchdown on 24 attempts.
His best performance in 2022 came against the Rams in Week 4, when the fourth-year pro had six receptions for 115 yards and contributed a 57-yard touchdown catch to the 49ers' 24-9 victory.
Including the 2021 NFC Championship Game, Samuel has amassed 621 yards from scrimmage with five total touchdowns in five meetings with the Rams dating back to Week 12 of the 2020 campaign. The 49ers won all four of the regular-season matchups between the teams during that stretch.
Shanahan added that fellow wide receiver Jauan Jennings will be listed as questionable for Sunday’s game due to a hamstring injury of his own.
Jennings ranks fourth among San Francisco players with 14 catches and 180 receiving yards in seven games this season.