N'Golo Kante's second-half strike was enough to settle a tense, and entertaining, game at Stamford Bridge. With a semi-final date with Tottenham now set for five weeks' time, the title tilt is again the sole focus.
The Premier League pacesetters, who ran out 4-2 winners over the Potters on New Year's Eve, are playing before the remaining top four - Tottenham, Manchester City and Liverpool - with Arsenal taking the Saturday's lunchtime kick-off.
A win will move them 13 points ahead of their rivals, with 10 games left to play, while Stoke will hope to build on a well-deserved 0-0 draw with City in their previous outing.
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Stoke City host Chelsea with kick-off scheduled for 3pm on Saturday, March 18.
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Victor Moses is Antonio Conte's only injury concern ahead of the game.
The wing-back was withdrawn in the final minutes of Monday's win over United and has reportedly picked up a calf strain.
His absence could see Pedro move to wing-back, after dropping to the bench for the FA Cup tie, and Willian retaining his place in attack.
Marko Arnautovic, Xherdan Shaqiri and Wilfried Bony return to the Stoke squad for the visit of Premier League leaders Chelsea.
Arnautovic missed the goalless draw with Manchester City through illness while Shaqiri has been absent for six matches with a series of niggling injuries, including a calf problem. Bony was ineligible at the Etihad Stadium under the terms of his loan agreement with City.
Glen Johnson (shoulder) remains out while Jack Butland returned to training this week as he steps up his recovery from a long-term ankle injury in the hope of making his comeback before the season ends.
Provisional squad: Grant, Given, Shawcross, Pieters, Bardsley, Martins Indi, Muniesa, Cameron, Whelan, Adam, Imbula, Allen, Afellay, Arnautovic, Sobhi, Shaqiri, Walters, Crouch, Berahino, Diouf, Bony.
Stoke City starting XI: Grant; Bardsley, Shawcross, M.Indi, Pieters; Diouf, Cameron, Allen, Sobhi; Walters, Berahino
Chelsea starting XI: Courtois; Azpilicueta, Luiz, Cahill; Pedro, Fabregas, Kante, Alonso; Willian, Costa, Hazard
BETTING ODDS (via 888 Sport)
Stoke City to win: 25/7
Chelsea to win: 5/9
Click here to place a bet. Odds correct as of March 17 at 2.30pm.