The 11th career gold for the former swimmer, who switched to cycling in 2005, moved her equal with former wheelchair racer Baroness Tanni Grey-Thompson.
But Storey has also won seven silvers and three bronze medals, trumping Grey-Thompson's four silvers and one bronze.
"It's a dream come true," said Storey. "To equal Tanni's achievements is a huge honour. Her career was absolutely immense.
"She's an absolutely incredible girl and I can't wait to give her a big hug.
"This year I have just left no stone unturned in my training and tried my hardest to make sure everything is right with my nutrition and everything.
"I had to make sure that I paced it right when I was away because anyone can blow up, even if you have got a five-minute lead so I made sure I wasn't getting too excited.
"The crowd were absolutely amazing, all around the circuit, I can't thank them enough."
Swimmer Mike Kenny won 16 golds and two silvers between 1976 and 1988 but records in the earlier years still remain sketchy so it is difficult to be definitive about who is the greatest of all time.
However, there is no doubting after a week to remember that Storey is right up there in the conversation.
She attacked from the start of the 64km, eight-lap race and finished seven minutes and 22 seconds clear of her nearest rival, Poland's Anna Harkowska, covering the course at an average of 38kph.
Storey even caught the competitors in the men’s C1-3 event, who started their race two minutes before the women, and the men’s event had to be neutralised by officials when they tried to race alongside her.
“I'd completely forgotten about the men until I could see the back of their peloton. I just managed to hold them off but I was dying,” added Storey.
Earlier, Jon-Allan Butterworth ended his first Paralympic Games with three silver medals from five events, having abandoned the road race after four of the ten laps because he was struggling to keep up with the pack.
Butterworth, a former RAF serviceman who lost his arm in a rocket attack in Iraq, was involved in a training accident on Tuesday and raced with a heavily bandaged right arm and cuts on his leg.
“There are various areas I can improve on and road isn’t something I’ve really tapped into yet,” he said.
“There are so many things I can do on the track to get better and I’m already top two in the world in every track event so I’m not doing too bad but come Rio hopefully I will be unstoppable."