It was a gritty all-round performance from Tatum as he also finished with 34 points, six assists and three steals, imposing his will on the game despite shooting an inefficient nine-of-27 from the field and committing seven turnovers.
Like Tatum, his All-Star team-mate Jaylen Brown also shot just 33 per cent from the field (six-of-18), but veteran center Al Horford picked up the slack, scoring 20 points on eight-of-13 shooting while adding 10 rebounds and three blocks.
As was a theme on the night, Warriors superstar Stephen Curry struggled from the field, shooting nine-of-25 for his 29 points, supplementing his outing with seven assists, four steals, four rebounds and two blocks. Klay Thompson (eight-of-16) and Jordan Poole (10-of-25) chipped in 24 points each.
With the win, the Celtics improved their league-leading record to 34-12, while the Warriors fell under .500 at 22-23, including a horrific 5-17 record on the road.
Russell leads late Timberwolves comeback
Minnesota Timberwolves guard D'Angelo Russell nearly scored as many points as the entire Toronto Raptors team in the fourth quarter of a 128-126 comeback win.
Russell had 16 in the last period – including 14 in a row for the Timberwolves – while the Raptors could only muster 17 points, allowing the home side to claw back from what was a 14-point margin with 10 minutes remaining.
The former All-Star finished with 25 points on eight-of-15 shooting, adding six assists and two steals, while role-player Kyle Anderson continued to flourish in his expanded minutes with 20 points (eight-of-nine), 10 rebounds and six assists.
In the battle of two short-handed teams, the Phoenix Suns ended their three-game losing streak in a nail-biting 117-112 victory over the Brooklyn Nets.