Ronald Koeman will start three Under-21s in Saturday's Merseyside derby, with the Everton boss having to make use of his squad players in lieu of the injured Seamus Coleman, Ramiro Funes Mori and Muhamed Besic.
The Dutch boss will line up with three at the back as his side look for their first Premier League win at Anfield since 1999.
Jurgen Klopp has restored Dejan Lovren and Lucas to his first XI in the Merseyside derby as he looks to extend Liverpool’s unbeaten run against Everton to 13 matches.
The centre-back replaces Ragnar Klavan, while the Brazilian is drafted into the midfield with both Jordan Henderson (foot) and Adam Lallana (thigh) sidelined.
The selection of the duo are the only changes to the starting XI that drew 1-1 at Manchester City prior to the international break.
Marko Grujic, on the bench, is named in a Premier League squad for the first time since the goalless draw with Southampton on November 19.
Liverpool starting XI: Mignolet, Clyne, Matip, Lovren, Milner, Lucas, Can, Wijnaldum, Mane, Coutinho, Firmino
Liverpool subs: Karius, Klavan, Moreno, Alexander-Arnold, Grujic, Woodburn, Origi
Everton starting XI:Robles, Holgate, Williams, Jagielka, Pennington, Baines, Davies, Gana, Barkley, Calvert-Lewin, Lukaku
Everton subs:Stekelenburg, Kone, Mirallas, Barry, Valencia, Lookman, Kenny