Teenage wing Louis Rees-Zammit is among five uncapped players in new Wales head coach Wayne Pivac's squad for the Six Nations.
Rees-Zammit has earned rave reviews following his performances for Gloucester and the 18-year-old flyer is set to be unleashed on the international stage.
Prop WillGriff John, second-row Will Rowlands, centre Nick Tompkins and versatile New Zealand-born back Johnny McNicholl will also be hoping to win their first caps for the defending champions.
Lock Seb Davies and wing Jonah Holmes are among the 38 included by Pivac along with fit-again back-row Taulupe Faletau and scrum-half Rhys Webb, who is set to re-join the Ospreys from Toulon.
"We are really excited to be naming our Six Nations squad and kicking the campaign off," said Pivac.
"A lot of time and effort has gone into selecting the squad, all of the coaches have been out and about, seeing players in training, speaking with them and we are pretty excited with the group we have got.
"Looking back to the Barbarians week, that was hugely important for us. We got a lot of 'firsts' out of the way, getting to meet and get in front of the players and having a game together was hugely beneficial.
"We do have a couple of injuries but we flip that into seeing it as an opportunity for some new players to impress, with not only the Six Nations in mind but also longer term and 2023."
Wales squad in full:
Forwards: Rhys Carre, Rob Evans, Wyn Jones, Elliot Dee, Ryan Elias, Ken Owens, Leon Brown, WillGriff John, Dillon Lewis, Jake Ball, Adam Beard, Seb Davies, Alun Wyn Jones (captain), Will Rowlands, Cory Hill, Aaron Shingler, Aaron Wainwright, Taulupe Faletau, Ross Moriarty, Josh Navidi, Justin Tipuric.
Backs: Gareth Davies, Rhys Webb, Tomos Williams, Dan Biggar, Owen Williams, Jarrod Evans, Hadleigh Parkes, Nick Tompkins, Owen Watkin, George North, Josh Adams, Owen Lane, Johnny McNicholl, Louis Rees-Zammit, Jonah Holmes, Leigh Halfpenny, Liam Williams.